ea0098c44 | Clinical – Surgery/Applied Pathology | NANETS2023
D Bell, Katelyn Smith Phoenix
, Paniccia Alessandro
, K Lee Kenneth
, F Pingpank James
, Hogg Melissa
, J Zeh Herbert
, N Nikiforov Marina
, D Singhi Aatur
, H Zureikat Amer
Background: Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms with increasing incidence and unpredictable behavior. Whole-exome sequencing studies of metastatic PanNETs have found recurrent genomic alterations in DAXX and ATRX, which correlate with corresponding loss of protein expression. Loss of DAXX/ATRX in PanNETs is reported to be associated with several, adverse clinicopathologic features and poor patient disease-free survival (DFS). Howev...